BackgroundCrestor (CRESTOR) is a widely used statin for heart failure and is also approved for use in combination with other statins. It is prescribed primarily for patients with moderate-to-severe heart failure who have not achieved the goal of achieving an adequate reduction in fluid and electrolyte levels. In addition to this use in combination with other statins, CRESTOR can also be prescribed for patients with advanced-stage HF, as well as patients at risk of cardiovascular events. CRESTOR has been shown to be effective in improving survival in patients with decompensated heart failure. CRESTOR has been extensively studied in patients with severe HF who have not achieved their target reduction in fluid and electrolyte levels and/or preserved ejection fraction (eGFR). The use of CRESTOR in these patients is generally considered safe and has been extensively researched. However, there is currently limited research evaluating the effects of CRESTOR on the overall survival (OS) and survival in patients with decompensated heart failure with preserved ejection fraction (HFpEF) at the time of presentation. This study was conducted to evaluate the effect of CRESTOR on the OS of patients with decompensated HFpEF with preserved ejection fraction (HFpEF-pEF), as well as to assess whether CRESTOR is associated with an increase in mortality and overall survival. A prospective, multicentre, randomized, double blind, placebo controlled trial was performed in this study. Data was collected on all patients presenting to our clinic at the beginning of the trial for a period of 12 weeks. We assessed the treatment-emergent adverse events (AEEs) using the International Classification of Adverse Events (ICAE) and overall survival (OS) using the Kaplan-Meier method. Data was analyzed using the intention to treat model and compared using the log-rank test. Patients were included in the study if they met the following criteria: 1) they had a baseline clinical diagnosis of heart failure (HFpEF), including decompensated HF (HFpEF-pEF ≥ 40) and/or HF failure (HFpEF ≥ 20) plus a baseline creatinine ≥ 1.9 mg/dL (defined as a Creatinine <1.9 mg/dL for a defined range of 1.0 to ≥2.0 mg/dL); 2) a baseline ejection fraction (EF) <20% and at least 2% at baseline, with a baseline creatinine >1.2 mg/dL (defined as a creatinine >1.2 mg/dL with a defined range of 0.4 to 2.0 mg/dL); 3) a baseline body mass index (>30 kg/m2 with a defined range of 28 to 29 kg/m2); and 4) a baseline hemoglobin >12 g/dL (defined as a hemoglobin >12 g/dL). CRESTOR was started at a dose of 10 mg/day with subsequent doses titrated up to 20 mg/day. The primary outcome was a reduction in the change from baseline in the number of days on treatment with CRESTOR. There were no significant differences between the groups in terms of change from baseline in the number of days on treatment with CRESTOR. There were significantly fewer patients in the CRESTOR group who had experienced AEs/AEs in the course of the trial (median 8; IQR 2 to 12). The primary outcome measure was the change in the number of days on CRESTOR (defined as the number of days on treatment with CRESTOR divided by the number of days on treatment with placebo). The results from this trial showed that CRESTOR reduced the number of days on treatment with CRESTOR from 4 to 12, but this was not significantly different from placebo in terms of change from baseline in the number of days on treatment with CRESTOR (3). AEs/AEs from the CRESTOR group were more common in patients with HFpEF-pEF > 40, and in patients with HFpEF-pEF > 20. AEs in the course of the trial were less common in patients with HFpEF-pEF > 40, and in patients with HFpEF-pEF > 20. The results from this trial suggest that CRESTOR is safe in patients with HFpEF-pEF > 20 and is safe in patients with HFpEF-pEF > 40. This is an important study because the number of patients with HFpEF-pEF > 40 with preserved ejection fraction was small.
By Sophie Kang, Ernest Mario School of Pharmacy at Rutgers University
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Crestor is a statin used to lower cholesterol and reduce the risk of heart disease in adults over 40 who are not candidates for low-dose statin therapy, or trial-and-error models, or have coronary artery disease. It is also used to prevent heart attacks and stroke, as well as to treat oral delayed-type2 diabetes.
Crestor is thought to work by blocking the action of certain cholesterol-causing enzyme ( statins ) on the brain (LDL ) and arteries. This helps to block the absorption of up to three times more of the cholesterol from the meal, once the plodding phase of the plodding phase of the fasting phase.
Although Crestor is believed to be most effective in lowering cholesterol without causing side effects, it may also be prescribed to women who are unable to reach their normal menstrual periods due to an conditions such as polycystic ovary syndrome.
CRESTOR 10MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.
By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 10MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.
Before taking CRESTOR 10MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
CRESTOR 10MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 10MG TABLET as a precaution.
The most common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 10MG TABLET.
How should I take CRESTOR 10MG TABLETTake CRESTOR 10MG TABLET as directed by your doctor. Swallow whole with water. Do not crush or chew the tablet. Take CRESTOR 10MG TABLET orally with or without food, usually once daily in the first four weeks of taking CRESTOR 10MG TABLET. The dosage may be lower if you miss a dose, or taken with other anti-diabetic medications. The typical dose and duration of anti-diabetic medication used to treat diabetes is 2.5 mg to 5.0 mg per day, with or without food. It is used to manage type 2 diabetic diseases by reducing the amount of glucose absorbed from food.
USES OF CRESTOR 10MG TABLET
DRUGS AND USE
CLOMBBACKS
MAIN RESONDENCEclisin-
administered daily
CLOMBBACK
PRESCRIPTION
Prescription
STORAGE MECHANISMS
CRESTOR 10MG TABLET is different from other anti-diabetic medications by different factors. It is important to consult with your doctor before taking it as it may cause some side effects.
Some of the side effects of CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache, but these are typically harmless. However, you may experience more serious reactions, such as irregular heartbeat, including liver problems. Contact your doctor if you experience any of the following more serious side effects: allergic reactions, pain in the lower back and martingale muscle, pain in the upper right arm along with a sore stomach.
Serious side effects can include severe allergic reactions such as skin rash, itching, swollen glands, respiratory failure, signs of liver problems including abdominal pain, fluid retention,ever more frequently seen. You may need to be started at a dose different from the recommended dose for you. If you miss a dose, take your your doctor's dose as soon as you remember. If it is almost time for the next dose, but your healthcare provider is ready to take it, take it as soon as you remember.
GETID DISCONTINTS
CRESTOR 10MG TABLET may also causes you to have certain side effects. The most serious of which are free breathing, cough, sweating, fever, general feeling of pain, severe tiredness, confusion, severe pain, evidence of stomach bleeding, bloody or bloody stomach, nausea, vomiting, and severe pain in your lower back. This is a serious side effect and you should stop taking CRESTOR 10MG TABLET and ask your doctor for more information.
Some people who have this side effect have experienced allergic reactions. This is a rare reaction, but if you experience symptoms such as cough, coughles, hoarseness, shortness of breath, wheezing or difficulty breathing, you should contact your doctor immediately.
is used to relieve symptoms of high cholesterol (LDL) in patients with hyperlipidemia. It lowers LDL, a lipid parameter and also helps prevent cardiovascular diseases. It also reduces the risk of heart attack, stroke and other heart problems in patients with high cholesterol. Crestor is also used in combination with other medications to treat high cholesterol.
1. It reduces the risk of heart attack, heart failure, and other cardiovascular problems.
2. It helps prevent cholesterol from getting to your liver, kidneys and to the rest of your body.
3. It also prevents LDL from getting to your heart.
Crestor tablets are usually taken at a dose of one tablet (one tablet of 30 mg). The recommended maximum dosage for adults is two tablets per day. Crestor tablets should be taken at least one hour before or two hours after a meal. Crestor tablets should be stored at a temperature of 15-25 degrees Celsius. It may be taken with food. Crestor tablets should not be used in combination with other medicines that may interact with Crestor.
Crestor tablets are used to treat certain diseases, including:
Crestor is a medication that belongs to the class of statins and reduces the risk of heart attack, stroke and other heart diseases.
The side effects of Crestor tablets in Pakistan are very common, and can include:
Do not use Crestor tablets in the following ways:
Certain medicines may interact with Crestor tablets, and Crestor may interact with other medicines that you are taking. These medicines may affect your safety and effectiveness in certain cases.
Drugs that interact with Crestor tablets may increase the risk of kidney problems and may increase the risk of liver problems. If you are taking one of these medicines, you should not take Crestor tablets because Crestor may interact with other medicines that you are taking.
If you miss a dose of Crestor tablets, take it as soon as you remember. If it is near the time of the next dose, do not take it. It may be that you will need a different dose than what you were prescribed.
Store Crestor tablets at a temperature between 15-25 degrees Celsius.
Store Crestor tablets at room temperature below 30 degrees Celsius.
How does the drug interact with Crestor 10mg Tablet:Co-administration of Crestor 10mg Tablet with: Can increase the risk of cardiovascular events and renal dysfunction.How to manage the interaction:Co-administration of Rosuvastatin 10mg Tablet and Rosuvastatin 5mg Tablet is not recommended as it may cause serious interaction. Rosuvastatin is a pro-hypertensive medication. It may be used in combination with H2 blocker therapy or as an adjunct to isosorbide dinitrate to reduce the blood pressure levels. Rosuvastatin is an angiotensin-converting enzyme (AACE) inhibitor.Co-administration of Rosuvastatin 10mg Tablet with Rosuvastatin 5mg Tablet can increase the risk of cardiovascular events and renal dysfunction. The interaction between Rosuvastatin and Rosuvastatin is not recommended as it may cause serious interaction. It may be used in combination with H2 antagonist therapy to lower the blood pressure levels and improve cardiac symptoms.Co-administration of Rosuvastatin 10mg Tablet with Rosuvastatin 5mg Tablet can increase the risk of cardiovascular symptoms. It may be used in combination with H2 antagonist therapy or as an adjunct to isosorbide dinitrate to reduce the blood pressure levels.It may be used in combination with H2 antagonist therapy or as an adjunct to isosorbide dinitrate to lower the blood pressure levels.
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